49ers vs. Seahawks Prediction, Betting Tips & Picks – Week 2

by | Sep 14, 2022

The San Francisco 49ers (0-1) play a familiar opponent when they host the Seattle Seahawks (0-0) on Sunday, September 18, 2022 at Levi’s Stadium in an NFC West clash. Find more below on the 49ers vs. Seahawks betting line, injury report, head-to-head stats, best bets and more.

The 49ers (-10) are big favorites against the Seahawks. The total is set at 42.5 points.

49ers vs. Seahawks Spread and Betting Line

49ers vs Seahawks Betting Information
Favorite Spread Favorite spread odds Underdog spread odds Total Over total odds Under total odds
49ers -10 -110 -110 42.5 -110 -110

49ers vs. Seahawks Game Info

  • Game Day: Sunday, September 18, 2022
  • Game Time: 4:05 PM ET
  • TV Channel: FOX
  • Location: Santa Clara, California
  • Stadium: Levi’s Stadium

49ers vs. Seahawks Prediction and Computer Picks

Prediction for 49ers vs Seahawks
Spread Pick Total Pick Predicted Score
Seahawks (+10) Over (42.5) 49ers 25, Seahawks 19

49ers vs. Seahawks Betting Trends

  • Against the spread, the 49ers were 9-8-0 last season.
  • The 49ers covered every time (1-0) as a 10-point favorite or greater last year.
  • The 49ers had eight of its 17 games hit the over last season.
  • The 49ers scored 25.1 points per game last year, 3.6 more than the Seahawks gave up.
  • In games where the 49ers scored over 21.5 points last season, they were 9-2.
  • The Seahawks’ defense surrendered 379.1 yards per game last season, just 3.4 yards more than the 375.7 the 49ers’ offense averaged. The 49ers picked up 6.3 yards per play, while the Seahawks allowed 5.6.
  • The 49ers’ record last season when they racked up more than the Seahawks’ season average in total yards allowed (379.1): 6-2.
  • San Francisco 49ers Leaders

  • Last year Jimmy Garoppolo recorded 3,810 yards (254 per game), a 68.3% completion percentage, 20 touchdowns, and 12 interceptions.
  • Last year Elijah Mitchell took 207 carries for 963 yards (87.5 per game) and scored five touchdowns.
  • Nick Bosa did his thing last season with a huge stat line of 15.5 sacks, 21 TFL and 52 tackles.
  • Fred Warner went to work last year, collecting 137 tackles, seven TFL, and 0.5 sacks.
  • Tashaun Gipson intercepted two passes last year while also totaling 47 tackles, one TFL, one sack, and three passes defended.
  • San Francisco 49ers Season Stats

    Stat Average (Total) Rank
    Pass yards 248.3 (4221) 12
    Rush yards 127.4 (2166) 7
    Points scored 25.1 (427) 13
    Pass yards against 206.5 (3510) 6
    Rush yards against 103.5 (1760) 7
    Points allowed 21.5 (365) 9

    Seahawks vs. 49ers Betting Trends

  • The Seahawks had nine wins in 17 games against the spread last season.
  • Out of the 17 Seahawks’ games last year, six hit the over.
  • The Seahawks put roughly the same amount of points on the board per game last year (23.2) as the 49ers allowed (21.5).
  • When they went over what the 49ers gave up last year (21.5 points per game), the Seahawks were 7-2.
  • The 49ers’ defense gave up 310 yards per game last year, just 13.9 yards fewer than the 323.9 the Seahawks’ offense gained. The Seahawks picked up 6.2 yards per play, while the 49ers conceded 5.5.
  • When the Seahawks offense put together a game with more than the 49ers’ average yards conceded last year (310), the team was 5-4.
  • Seattle Seahawks Leaders

  • Drew Lock threw for an average of 131.2 yards passing per game and completed two touchdowns last season.
  • Rashaad Penny accumulated 749 rushing yards and six touchdowns on the ground during last year’s campaign.
  • Tyler Lockett was targeted 6.7 times per game and collected 1,175 receiving yards and eight touchdowns over the course of 2021.
  • Last year Darrell Taylor collected 6.5 sacks, seven TFL and 32 tackles.
  • Jordyn Brooks put together an excellent stat line last year, accruing 183 tackles, 10 TFL, and one sack.
  • A year ago Quandre Diggs collected 94 tackles, one TFL, and seven passes defended as well as five interceptions.
  • Seattle Seahawks Season Stats

    Stat Average (Total) Rank
    Pass yards 201.9 (3432) 23
    Rush yards 122 (2074) 11
    Points scored 23.2 (395) 16
    Pass yards against 265.5 (4513) 31
    Rush yards against 113.6 (1932) 17
    Points allowed 21.5 (366) 9

    49ers and Seahawks Injury Report

    Player Pos. Injury Status
    Player Pos. Injury Status

    49ers and Seahawks’ Recent Performance

    The 49ers enter this matchup after a 19-10 loss to the Chicago Bears in their most recent game. The Seahawks’ last game was a 17-16 win over the Denver Broncos. Against the Bears, Trey Lance led the Niners with 164 yards on 13-of-28 passing (46.4%) for no touchdowns and one interception. He also carried the ball 13 times for 54 yards. Deebo Samuel rushed for 52 yards on eight carries (6.5 yards per carry) and one touchdown, adding two receptions for 14 yards. Jauan Jennings hauled in four receptions for 62 yards (averaging 15.5 per catch) against the Bears. Geno Smith went 23-for-28 with 195 yards, two touchdowns and no interceptions for the Hawks against the Broncos. Penny carried the ball 12 times for 60 yards. He caught two passes for seven yards. Colby Parkinson caught two passes on two targets for 43 yards (21.5 yards per reception), and scored one touchdown.

    Betting Tips for 49ers vs. Seahawks

    After looking at all of the key stats and trends for this matchup, our best bet against the spread is Seahawks (+10). Our computer picks see the scoring going over the total of 42.5 points, with the teams finishing with a final score of 49ers 25, Seahawks 19 when all is said and done.

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