Giants vs. Padres Prediction, Betting Tips & Picks 5/21/2022

The San Francisco Giants (22-16) will look to Darin Ruf, who is coming off a two-homer game, to lead them in a matchup with the San Diego Padres (25-14) Saturday at 4:05 PM ET. The Giants are -146 favorites for the contest, according to bookmakers. Carlos Rodon will get the ball for San Francisco while San Diego counter with Joe Musgrove.

Giants vs. Padres Spread and Betting Line

Computer Predictions for Giants vs. Padres

Our computer pick: San Diego Padres (+125) and Over (7)

Giants vs. Padres Game Info

• San Francisco Giants probable starting pitcher: Carlos Rodón
• San Diego Padres probable starting pitcher: Joe Musgrove
• Game Day: Saturday, May 21, 2022
• Game Time: 4:05 PM ET
• Location: San Francisco, California
• Stadium: Oracle Park

San Francisco Giants vs San Diego Padres Pitching Matchup

Giants Starter Carlos Rodón

• Rodon gets the start for the Giants, his eighth of the season. He is 4-2 with a 3.49 ERA and 56 strikeouts in 38 2/3 innings pitched.
• The lefty’s last time out was on Sunday against the St. Louis Cardinals, when he went 3 2/3 innings, surrendering eight earned runs while giving up 10 hits.
• The 29-year-old has a 3.49 ERA and 13 strikeouts per nine innings in seven games this season, while giving up a batting average of .214 to his opponents.
• Rodon has four quality starts under his belt this year.
• Rodon has pitched five or more innings in a game six times this season entering this game.
• He will match up with a Padres offense that ranks 21st in MLB with 296 total hits (on a .228 batting average). The squad also slugs a collective .356 (21st in MLB) with 31 total home runs (22nd in MLB).
• Among qualifying pitchers in MLB action this season, the 29-year-old ranks 33rd in ERA (3.49), 26th in WHIP (1.112), and second in K/9 (13).

Padres Starter Joe Musgrove

• The Padres will send Musgrove (4-0) to the mound for his eighth start this season.
• The right-hander gave up two earned runs and allowed four hits in six innings pitched against the Atlanta Braves on Sunday.
• The 29-year-old has an ERA of 2.20 and 9.4 strikeouts per nine innings with an opponent batting average of .217 in seven games this season.
• He’s going for his eighth quality start in a row.
• Musgrove has pitched five or more innings in seven straight games and will look to extend that streak.
• The Giants rank fifth in MLB with a .248 batting average this season. They have a team slugging percentage that ranks ninth in the league (.395) and 42 home runs.
• Among qualified Major League pitchers this season, the 29-year-old’s 2.20 ERA ranks 10th, .933 WHIP ranks seventh, and 9.4 K/9 ranks 18th.

Giants Betting Picks & Insights

• The Giants have entered the game as favorites 31 times this season and won 20, or 64.5%, of those games.
• San Francisco has entered 17 games this season favored by -146 or more and is 11-6 in those contests.
• The oddsmakers’ moneyline implies a 59.3% chance of a victory for the Giants.
• San Francisco’s games have gone over the total in 21 of their 39 chances.
• The Giants are 18-20-0 against the spread this season.

Padres Betting Picks & Insights

• The Padres have come away with seven wins in the 13 contests they have been listed as the underdogs in this season.
• This season, San Diego has come away with a win two times in five chances when named as an underdog of at least +125 or worse on the moneyline.
• The moneyline set for this matchup implies the Padres have a 44.4% chance of walking away with the win.
• San Diego and their opponents have hit the over in 20 of their 40 games with a total set by oddsmakers this season.
• The Padres are 22-18-0 against the spread in their 40 games that had a posted line this season.

Giants Leaders & Batting Stats

• Thairo Estrada paces the Giants with a team-best batting average of .275.
• Estrada’s home runs put him 178th in MLB, and he is 49th in RBI.
• Estrada has collected a hit in four games in a row. During his last five outings he is hitting .500 with three doubles, two walks and two RBI.
• Wilmer Flores’ 22 runs batted in pace his team.
• Flores ranks 121st in home runs and 25th in RBI among all hitters in baseball.
• Flores has three straight games with at least one hit. In his last five games he is batting .263 with two doubles, a walk and three RBI.
• Ruf has five doubles, three home runs and 23 walks while batting .250.
• Brandon Crawford is batting .223 with five doubles, a triple, three home runs and 14 walks.
• Crawford has recorded at least one hit in three straight games. In his last five games he is hitting .278 with a triple, a walk and two RBI.

Padres Leaders & Batting Stats

• Manny Machado paces the Padres with seven home runs and 24 runs batted in, while posting a team-best batting average of .363.
• Machado’s home run total puts him 27th in the majors, and he ranks 18th in RBI.
• Machado takes a hitting streak of four games into this game. During his last five outings he is batting .389 with a double, a walk and an RBI.
• Eric Hosmer has driven in the most runs for the Padres with 24 runs batted in.
• Hosmer ranks 75th in homers and 18th in RBI among all hitters in MLB.
• Jurickson Profar is batting .207 with eight doubles, a triple, five home runs and 22 walks.
• Jake Cronenworth has six doubles, two triples, three home runs and 18 walks while batting .207.

Betting Tips for Giants vs. Padres

Our best bet is the Padres on the moneyline at +125 after taking a look at all of the key trends and stats for this matchup. Our computer projects the total score will over the total of 7 runs.