Angels vs. Guardians Prediction, Betting Tips & Picks 4/27/2022

The Cleveland Guardians (7-10) will try to end their five-game losing streak when they visit the Los Angeles Angels (11-7) on Wednesday at 9:38 PM ET. Bookmakers consider the Angels to be -202 favorites for the contest, while the Guardians are +170 underdogs looking for the upset. Shohei Ohtani starts for Los Angeles while Zach Plesac is Cleveland’s starter for the contest.

Angels vs. Guardians Spread and Betting Line

Computer Predictions for Angels vs. Guardians

Our computer pick: Cleveland Guardians (+170) and Over (7.5)

Angels vs. Guardians Game Info

• Los Angeles Angels probable starting pitcher: Shohei Ohtani
• Cleveland Guardians probable starting pitcher: Zach Plesac
• Game Day: Wednesday, April 27, 2022
• Game Time: 9:38 PM ET
• Location: Anaheim, California
• Stadium: Angel Stadium

Los Angeles Angels vs Cleveland Guardians Pitching Matchup

Angels Starter Shohei Ohtani

• Ohtani starts for the first time this season for the Angels.
• In three appearances this season, he has a 4.40 ERA and 16.3 strikeouts per nine innings, while opponents are batting .200 against him.
• The Guardians have scored 76 runs this season (10th in MLB) and are batting .250 collectively with 14 home runs (17th in the league).

Guardians Starter Zach Plesac

• The Guardians will hand the ball to Plesac (1-1) for his fourth start of the season.
• The right-hander gave up one earned run and allowed seven hits in 6 2/3 innings pitched against the Chicago White Sox on Thursday.
• The 27-year-old has pitched in three games this season with an ERA of 1.53, 5.1 strikeouts per nine innings and an opponent batting average of .258.
• In three starts this season, he’s earned a quality start in one of them.
• Plesac will look to pitch five or more innings for the third start in a row.
• The Angels are batting .248 this season, eighth in MLB. They have a team slugging percentage of .426 (second in the league) with 24 home runs.
• Among qualified Major League pitchers this season, the 27-year-old’s 1.53 ERA ranks sixth, 1.075 WHIP ranks 23rd, and 5.1 K/9 ranks 54th.

Angels Betting Picks & Insights

• The Angels have entered the game as favorites 15 times this season and won 10, or 66.7%, of those games.
• Los Angeles has played as a favorite of -202 or more twice this season and split those games.
• The Angels have a 66.9% chance to win this game based on the implied probability of the moneyline.
• Games involving Los Angeles have gone over the total set by sportsbooks in eight of 18 chances this season.
• The Angels are 9-9-0 against the spread this season.

Guardians Betting Picks & Insights

• The Guardians have won in four, or 33.3%, of the 12 contests they have been named as odds-on underdogs in this year.
• Cleveland has been listed as an underdog of +170 or more on two occasions this season and lost both games.
• The Guardians have an implied victory probability of 37% according to the moneyline set for this matchup.
• Cleveland and their opponents have hit the over in nine of their 18 games with a total set by oddsmakers this season.
• The Guardians have an against the spread mark of 8-10-0 in 18 games with a line this season.

Angels Leaders & Batting Stats

• Mike Trout provides the Angels with a shot of both power and average, leading the team in home runs with five and hitting at .347. He has also driven in eight runs this season.
• Among all hitters in MLB, Trout’s home run total places him fifth, and his RBI tally ranks him 67th.
• Trout carries a three-game hitting streak into this matchup. During his last five outings he is hitting .474 with a double, a triple, three home runs, two walks and five RBI.
• Brandon Marsh’s 14 runs batted in are a team-high mark.
• Marsh heads into this matchup looking for his fourth game in a row with a hit. During his last five outings he is hitting .417 with a double, a home run, two walks and six RBI.
• Taylor Ward has a double, three home runs and 10 walks while batting .353.
• Ward is on a two-game hitting streak entering this contest. In his last five games he is batting .400 with two home runs, five walks and four RBI.
• Ohtani has three doubles, three home runs and six walks while batting .213.

Guardians Leaders & Batting Stats

• Jose Ramirez leads the lineup with a batting average of .344, and paces the Guardians in home runs, with four and runs batted in with 21.
• In all of the majors, Ramirez ranks 11th in homers and first in RBI.
• Ramirez carries a 10-game hitting streak into this matchup. During his last 10 games he is hitting .250 with two doubles, a home run, four walks and seven RBI.
• Steven Kwan is batting .341 with five doubles, a triple and nine walks.
• Among all MLB hitters, Kwan ranks 238th in home runs and 101st in RBI.
• Owen Miller has seven doubles, two home runs and five walks while batting .432.
• Myles Straw is batting .273 with two doubles, a triple and nine walks.

Betting Tips for Angels vs. Guardians

After digging through all of the key trends and statistics for this matchup, our best bet is the Guardians on the moneyline at +170. Our computer prediction sees the scoring going over the total of 7.5 runs.