Astros vs. Guardians Prediction, Betting Tips & Picks 5/25/2022

Two of the league’s top power hitters will meet Wednesday when the Houston Astros (28-16) and Cleveland Guardians (18-21) take the field at 8:10 PM ET. Yordan Alvarez has 12 home runs for the Astros (-184 favorites on the moneyline) while Jose Ramirez has 11 homers this season for the Guardians (+158). Cristian Javier will get the ball for Houston while Cleveland counter with Cal Quantrill.

Astros vs. Guardians Spread and Betting Line

Computer Predictions for Astros vs. Guardians

Our computer pick: Cleveland Guardians (+158) and Over (8)

Astros vs. Guardians Game Info

• Houston Astros probable starting pitcher: Cristian Javier
• Cleveland Guardians probable starting pitcher: Cal Quantrill
• Game Day: Wednesday, May 25, 2022
• Game Time: 8:10 PM ET
• Location: Houston, Texas
• Stadium: Minute Maid Park

Houston Astros vs Cleveland Guardians Pitching Matchup

Astros Starter Cristian Javier

• Javier (2-2 with a 2.87 ERA and 39 strikeouts in 31 1/3 innings pitched) gets the start for the Astros, his fifth of the season.
• The right-hander last pitched on Saturday against the Texas Rangers, when he threw six innings, allowing one earned run while giving up three hits.
• The 25-year-old has a 2.87 ERA and 11.2 strikeouts per nine innings in eight games this season, while giving up a batting average of .200 to his opponents.
• He will match up with a Guardians offense that ranks 24th in MLB with 324 total hits (on a .245 batting average). The team also slugs a collective .391 (14th in MLB) with 36 total home runs (22nd in MLB).

Guardians Starter Cal Quantrill

• The Guardians will send Quantrill (1-2) to the mound for his eighth start this season.
• The right-hander’s last appearance was on Thursday, when he threw seven innings against the Cincinnati Reds, giving up one earned run while allowing five hits.
• The 27-year-old has pitched to a 3.48 ERA this season with 5.4 strikeouts per nine innings compared to 3.3 walks per nine across seven games.
• In seven starts this season, he’s earned a quality start in four of them.
• Quantrill has pitched five or more innings in five straight games and will look to extend that streak.
• The Astros have scored 188 runs this season, which ranks 12th in MLB. They are batting .230 for the campaign with 59 home runs, third in the league.
• The 27-year-old ranks 30th in ERA (3.48), 34th in WHIP (1.185), and 54th in K/9 (5.4) among qualified pitchers in the majors this season.

Astros Betting Picks & Insights

• The Astros have been favorites in 34 games this season and won 24 (70.6%) of those contests.
• Houston has been at least a -184 moneyline favorite nine times this season and won each of those games.
• The implied probability of a win from the Astros, based on the moneyline, is 64.8%.
• So far this season, Houston and its opponents have hit the over in 12 of their 44 games with a total.
• The Astros are 23-21-0 ATS in their 44 games with a spread this season.

Guardians Betting Picks & Insights

• The Guardians have been underdogs in 29 games this season and have come away with the win 13 times (44.8%) in those contests.
• Cleveland has a win-loss record of 2-5 when favored by +158 or worse by bookmakers this year.
• The Guardians have an implied victory probability of 38.8% according to the moneyline set by sportsbooks for this matchup.
• Cleveland and its opponents have gone over the total this season in 23 of their 43 opportunities.
• The Guardians are 21-22-0 against the spread in their 43 games that had a posted line this season.

Astros Leaders & Batting Stats

• Alvarez’s 12 homers in 2022 are the most on the Astros. He’s also driven in 25 runs while hitting .250.
• Of all hitters in the majors, Alvarez’s home run total places him second, and his RBI tally puts him 25th.
• Kyle Tucker has collected 29 runs batted in to pace his team.
• Tucker ranks 26th in home runs and 15th in RBI among all hitters in baseball.
• Alex Bregman has 11 doubles, six home runs and 26 walks while batting .230.
• Bregman will look to build on his three-game hitting in this game. During his last five outings he is hitting .278 with two doubles, a home run, two walks and four RBI.
• Jose Altuve has six doubles, nine home runs and 11 walks while batting .289.
• Altuve takes a three-game streak with at least one hit into this one. During his last five outings he is batting .429 with four doubles, a home run and an RBI.

Guardians Leaders & Batting Stats

• Ramirez leads the Guardians with 11 home runs and 43 runs batted in, while posting a team-best batting average of .293.
• Among all hitters in MLB, Ramirez ranks fifth in homers and first in RBI.
• Ramirez carries a two-game hitting streak into this matchup. In his last five games he is batting .368 with two doubles, a triple, three home runs, two walks and 10 RBI.
• Myles Straw is hitting .247 with nine doubles, a triple and 23 walks.
• Straw is 325th among all batters in the big leagues in homers, and 292nd in RBI.
• Owen Miller is hitting .282 with 12 doubles, four home runs and 12 walks.
• Steven Kwan has six doubles, a triple, a home run and 17 walks while hitting .264.

Betting Tips for Astros vs. Guardians

After looking at all of the key trends and statistics for this matchup, our best bet is the Guardians on the moneyline at +158. Our computer picks see the scoring going over the total of 8 runs.