Cardinals vs. Cubs Prediction, Computer Picks, Odds & Pitching Matchup 6/25/2022

Seeking their 41st win of the year, the St. Louis Cardinals (40-33) are favorites (-200) on the moneyline when they take on the Chicago Cubs (27-44) Saturday at 2:15 PM ET. Miles Mikolas will get the ball for St. Louis while Chicago counter with Adrian Sampson.

Cardinals vs. Cubs Spread and Betting Line

Computer Predictions for Cardinals vs. Cubs

After looking at all of the key stats and trends for this matchup, our best bet is the Cubs on the moneyline at +170. Our computer picks see the scoring going over the total of 9 runs.

Our computer pick: Chicago Cubs (+170) and Over (9)

Cardinals vs. Cubs Game Info

• St. Louis Cardinals probable starting pitcher: Miles Mikolas
• Chicago Cubs probable starting pitcher: Adrian Sampson
• Game Day: Saturday, June 25, 2022
• Game Time: 2:15 PM ET
• Location: St. Louis, Missouri
• Stadium: Busch Stadium

St. Louis Cardinals vs Chicago Cubs Pitching Matchup

Cardinals Starter Miles Mikolas

• Mikolas makes the start for the Cardinals, his 15th of the season. He is 5-5 with a 2.64 ERA and 69 strikeouts in 88 2/3 innings pitched.
• In his most recent time out on Tuesday, the right-hander went 6 1/3 innings against the Milwaukee Brewers, allowing two earned runs while surrendering four hits.
• The 33-year-old has put up a 2.64 ERA and 7 strikeouts per nine innings across 14 games this season, while giving up a batting average of .208 to his opponents.
• Mikolas is trying to prolong a third-game quality start streak in this outing.
• Mikolas will look to go five or more innings for his 14th straight start. He’s averaging 6.1 innings per outing.
• He will take the mound against a Cubs offense that ranks 13th in MLB with 587 total hits (on a .244 batting average). The squad also slugs a collective .391 (16th in MLB) with 70 total home runs (17th in MLB).
• Mikolas has thrown five innings, giving up four earned runs on eight hits while striking out four against the Cubs this season.
• Among pitchers who qualify in MLB play this season, the 33-year-old ranks 11th in ERA (2.64), 11th in WHIP (.970), and 53rd in K/9 (7).

Cubs Starter Adrian Sampson

• Sampson gets the nod for the Cubs and will make his first start of the season.
• The 30-year-old righty will start for the first time this season after coming out of the bullpen twice.
• He has pitched in two games this season with an ERA of 1.59, a strikeout to walk ratio and a WHIP of .529.
• The Cardinals rank fourth in MLB with 346 runs scored this season. They have a .253 batting average this campaign with 76 home runs (13th in the league).

Cardinals Betting Picks & Insights

• The Cardinals have won 24, or 63.2%, of the 38 games they’ve played as favorites this season.
• St. Louis has a record of 2-2 in games where bookmakers favor them by at least -200 on the moneyline.
• The implied probability of a win from the Cardinals, based on the moneyline, is 66.7%.
• St. Louis’ games have gone over the total in 37 of their 74 chances.
• In 73 games with a spread this season, the Cardinals are 40-33-0 ATS.

Cubs Betting Picks & Insights

• The Cubs have been chosen as underdogs in 50 games this year and have walked away with the win 19 times (38%) in those games.
• This season, Chicago has been victorious one time in seven chances when named as an underdog of at least +170 or longer on the moneyline.
• The moneyline set for this matchup implies the Cubs have a 37% chance of coming away with a victory in the contest.
• Chicago and their opponents have gone over in 36 of their 71 games with a total set by sportsbooks this season.
• The Cubs have posted a record of 35-36-0 against the spread this season.

Cardinals Leaders & Batting Stats

• Paul Goldschmidt leads the Cardinals with 17 home runs and 61 runs batted in, while putting up a team-best batting average of .336.
• In all of Major League Baseball, Goldschmidt is 10th in home runs and third in RBI.
• Nolan Arenado has 18 doubles, 14 home runs and 27 walks while hitting .277.
• Arenado ranks 22nd in homers and 10th in RBI among all batters in the majors.
• Tommy Edman has 11 doubles, three triples, seven home runs and 29 walks while batting .275.
• Harrison Bader is hitting .258 with seven doubles, three triples, five home runs and 12 walks.

Cubs Leaders & Batting Stats

• Ian Happ leads the team in batting average with a high-water mark of .288.
• Happ is 82nd in homers and 50th in RBI among all hitters in the majors.
• Happ takes a hitting streak of seven games into this game. In his last 10 games he is batting .371 with four doubles, a home run, three walks and six RBI.
• Willson Contreras is hitting .265 with 13 doubles, a triple, 12 home runs and 28 walks.
• Contreras is 39th in home runs and 110th in RBI among all MLB batters this year.
• Patrick Wisdom has been solid source of run production for the Cubs with 14 long balls and 37 runs batted in.
• Nico Hoerner has six doubles, three triples, four home runs and seven walks while hitting .286.