Chiefs vs. Cardinals Prediction, Betting Tips & Picks – Week 1

by | Sep 1, 2022

The Kansas City Chiefs (0-0) and the Arizona Cardinals (0-0) play at State Farm Stadium on Sunday, September 11, 2022. Find more below on the Chiefs vs. Cardinals betting line, injury report, head-to-head stats, best bets and more.

The Chiefs are 4.5-point favorites in their matchup with the Cardinals. The over/under is 53.5 points.

Chiefs vs. Cardinals Spread and Betting Line

Chiefs vs Cardinals Betting Information
Favorite Spread Favorite spread odds Underdog spread odds Total Over total odds Under total odds
Chiefs -4.5 -110 -110 53.5 -111 -109

Chiefs vs. Cardinals Game Info

  • Game Day: Sunday, September 11, 2022
  • Game Time: 4:25 PM ET
  • TV Channel: CBS
  • Location: Glendale, Arizona
  • Stadium: State Farm Stadium

Chiefs vs. Cardinals Prediction and Computer Picks

Prediction for Chiefs vs Cardinals
Spread Pick Total Pick Predicted Score
Cardinals (+4.5) Under (53.5) Cardinals 26, Chiefs 25

Chiefs vs. Cardinals Betting Trends

  • The Chiefs’ record against the spread last year was 8-9-0.
  • The Chiefs’ ATS record as 4.5-point favorites or more was 5-6 last season.
  • There were 10 Chiefs games (out of 17) that hit the over last year.
  • The Chiefs scored 28.2 points per game last season, 6.7 more than the Cardinals gave up.
  • The Chiefs were 9-3 overall when scoring over 21.5 points last year.
  • The Chiefs’ offense averaged 396.8 yards per game last year, 67.6 more than the 329.2 the Cardinals’ defense allowed. The Chiefs earned 6.1 yards per play, while the Cardinals allowed 5.7.
  • The Chiefs’ record last year when they racked up more than the Cardinals’ season average in total yards allowed (329.2): 10-5.
  • Kansas City Chiefs Leaders

  • Patrick Mahomes II’s previous season stat line: 4,839 passing yards (284.6 per game), 436-for-658 (66.3%), 37 touchdowns and 13 picks. He also ran for 381 yards on 66 carries with two rushing TDs.
  • Last year Clyde Edwards-Helaire took 119 rushing attempts for 517 yards (30.4 per game) and scored four touchdowns.
  • Travis Kelce reeled in 92 catches for 1,125 yards (66.2 per game) while being targeted 134 times. He also scored nine touchdowns.
  • Chris Jones’ hard work last season put together a stat line of 9.0 sacks, 8.0 TFL and 27 tackles.
  • Nick Bolton went to work last year, collecting 112 tackles and 11.0 TFL.
  • L’Jarius Sneed collected two interceptions while adding 76 tackles, 7.0 TFL, one sack, and eight passes defended last year.
  • Kansas City Chiefs Season Stats

    Stat Average (Total) Rank
    Pass yards 281.8 (4791) 4
    Rush yards 115.0 (1955) 16
    Points scored 28.2 (480) 4
    Pass yards against 251.4 (4273) 27
    Rush yards against 117.6 (1999) 21
    Points allowed 21.4 (364) 8

    Cardinals vs. Chiefs Betting Trends

  • Cardinals posted a 10-7-0 record against the spread last year.
  • The Cardinals went unbeaten ATS (3-0) as underdogs of 4.5 points or more last season.
  • There were eight Cardinals games (out of 17) that went over the total last season.
  • The Cardinals scored 26.4 points per game last season, 5.0 more than the Chiefs allowed.
  • When they went over what the Chiefs gave up last season (21.4 points per game), the Cardinals were 10-2.
  • The average number of yards the Cardinals’ offense put up and the Chiefs’ defense gave up last season was within 4.7 yards (373.6 compared to 368.9). The Cardinals averaged 5.9 yards per play, while the Chiefs gave up 6.1.
  • In contests where the Cardinals offense totaled more than the Chiefs’ average yard allowance last season (368.9), the team was 8-3.
  • Arizona Cardinals Leaders

  • Kyler Murray threw for 3,787 yards and 24 touchdowns last season. He also chipped in with his legs, accumulating five touchdowns while racking up 423 yards.
  • James Conner averaged 44.2 rushing yards per game and collected 15 rushing touchdowns. Conner added 2.2 receptions per game to average 22.1 receiving yards.
  • Marquise Brown averaged 59.3 yards on 5.4 receptions per game and racked up six receiving touchdowns in 2021.
  • Markus Golden proved to be a strong defender last year, recording 11.0 sacks, 10.0 TFL and 48 tackles.
  • Jalen Thompson had an impressive defensive performance last season with 120 tackles, 3.0 TFL, and three interceptions.
  • Last year Byron Murphy intercepted four passes to go along with 64 tackles, 0.5 sacks, and 12 passes defended.
  • Arizona Cardinals Season Stats

    Stat Average (Total) Rank
    Pass yards 251.5 (4276) 10
    Rush yards 122.1 (2076) 10
    Points scored 26.4 (449) 11
    Pass yards against 214.4 (3645) 7
    Rush yards against 114.8 (1952) 20
    Points allowed 21.5 (366) 9

    Chiefs and Cardinals Injury Report

    Player Pos. Injury Status
    Player Pos. Injury Status

    Chiefs and Cardinals’ Recent Performance

    The Chiefs finished 12-5 last season and were knocked out of the playoffs in the Conference Championship round. They scored 28.2 points per game (fourth in the league) while allowing 21.4 (eighth). The Cardinals’ 2021 record was 11-6, and they fell in the Wild Card round of the playoffs. They averaged 26.4 points per game on offense (11th in the NFL) while giving up 21.5 per contest on defense (ninth).

    Betting Tips for Chiefs vs. Cardinals

    We have the Cardinals (+4.5) as our best bet in this game after taking a look at all of the key trends and statistics for this matchup. Our computer predicts the total score will finish under the total of 53.5 points, with a final score of Cardinals 26, Chiefs 25.

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