Cubs vs. Diamondbacks Prediction, Betting Tips & Picks 5/20/2022

The Chicago Cubs (15-22) are set to take on the Arizona Diamondbacks (19-21) Friday at 2:20 PM ET. The Cubs are listed as -132 favorites by bookmakers, while the underdog Diamondbacks have +112 odds for the contest. Kyle Hendricks will get the ball for Chicago while Arizona counter with Humberto Castellanos.

Cubs vs. Diamondbacks Spread and Betting Line

Computer Predictions for Cubs vs. Diamondbacks

Our computer pick: Arizona Diamondbacks (+112) and Over (11)

Cubs vs. Diamondbacks Game Info

• Chicago Cubs probable starting pitcher: Kyle Hendricks
• Arizona Diamondbacks probable starting pitcher: Humberto Castellanos
• Game Day: Friday, May 20, 2022
• Game Time: 2:20 PM ET
• Location: Chicago, Illinois
• Stadium: Wrigley Field

Chicago Cubs vs Arizona Diamondbacks Pitching Matchup

Cubs Starter Kyle Hendricks

• Hendricks (2-3) gets the starting nod for the Cubs in his ninth start of the season. He’s put together a 4.03 ERA in 44 2/3 innings pitched, with 32 strikeouts.
• The righty last pitched on Sunday against the Arizona Diamondbacks, when he tossed 5 2/3 innings, allowing one earned run while giving up five hits.
• The 32-year-old has amassed a 4.03 ERA and 6.4 strikeouts per nine innings in eight games this season, while allowing a batting average of .243 to opposing hitters.
• Hendricks is trying to pick up his third quality start of the season in this outing.
• Hendricks is seeking his fourth straight outing lasting five or more innings. He averages 5.2 innings per appearance on the mound.
• He will take the hill against a Diamondbacks squad that is batting .205 as a unit (29th in MLB). It is also slugging a collective .354 (22nd in MLB) with 42 total home runs (seventh in MLB).
• Hendricks has thrown 5 2/3 innings, giving up one earned run on five hits while striking out two against the Diamondbacks this season.
• The 32-year-old ranks 45th in ERA (4.03), 44th in WHIP (1.254), and 51st in K/9 (6.4) among qualifying pitchers in MLB action this season.

Diamondbacks Starter Humberto Castellanos

• The Diamondbacks will hand the ball to Castellanos (2-1) for his seventh start of the season.
• The right-hander’s last appearance was on Sunday, when he threw 5 1/3 innings against the Chicago Cubs, giving up two earned runs while allowing five hits.
• The 24-year-old has an ERA of 4.15, a 2.625 strikeout to walk ratio and a WHIP of 1.187 in eight games this season.
• Castellanos has not earned a quality start in six starts this season.
• Castellanos will look to pitch five or more innings for the fourth start in a row.
• The Cubs are batting .231 this season, 18th in MLB. They have a team slugging percentage of .363 (19th in the league) with 29 home runs.
• This season, the right-hander has pitched against the Cubs in one game, and they have gone 5-for-21 with a double, two home runs and two RBI over 5 1/3 innings.

Cubs Betting Picks & Insights

• The Cubs have won four of the 10 games they’ve played as favorites this season.
• Chicago is 3-4 this season when entering a game favored by -132 or more on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Cubs have a 56.9% chance to win.
• Chicago and its opponents have hit the over in 16 of their 37 games with a total this season.
• In 37 games with a spread this season, the Cubs are 20-17-0 ATS.

Diamondbacks Betting Picks & Insights

• The Diamondbacks have come away with 18 wins in the 39 contests they have been listed as the underdogs in this season.
• Arizona has a win-loss record of 14-18 when favored by +112 or worse by bookmakers this year.
• Bookmakers have implied with the moneyline set for this matchup that the Diamondbacks have a 47.2% chance of pulling out a win.
• Arizona and their opponents have gone over in 18 of their 45 games with a total set by sportsbooks this season.
• The Diamondbacks have posted a record of 26-19-0 against the spread this season.

Cubs Leaders & Batting Stats

• Willson Contreras has been great at getting on base for the Cubs this season, leading the team with a .391 OBP and 30 hits.
• Of all batters in MLB, Contreras ranks 53rd in home runs and 117th in RBI.
• Ian Happ’s .272 batting average leads his team.
• Among all major league hitters, Happ ranks 118th in home runs and 74th in RBI.
• Seiya Suzuki has sent home a team-high 18 runs batted in.
• Patrick Wisdom has shown off his power as he leads his team with six home runs.

Diamondbacks Leaders & Batting Stats

• Christian Walker paces the Diamondbacks in home runs (nine) and runs batted in (18).
• Walker ranks ninth in home runs and 67th in RBI among all hitters in the majors.
• Daulton Varsho’s .252 batting average is a team-high mark.
• Among all MLB hitters, Varsho ranks 25th in homers and 74th in RBI.
• Ketel Marte is batting .231 with 13 doubles, a triple, two home runs and 13 walks.
• David Peralta is batting .212 with six doubles, five home runs and 15 walks.

Betting Tips for Cubs vs. Diamondbacks

We have the Diamondbacks on the moneyline at +112 on the moneyline as our best bet in this contest after taking a look at all of the key trends and statistics for this matchup. Our computer prediction sees the scoring going over the total of 11 runs.