ACC opponents match up when the Florida State Seminoles (2-0) and the Louisville Cardinals (1-1) play on Friday, September 16, 2022 at Cardinal Stadium. Find more below on the Seminoles vs. Cardinals betting line, injury report, head-to-head stats, best bets and more.
The Seminoles are favored, but by less than a field goal (-2), versus the Cardinals. The over/under for this game is 54.5 points.
Table of Contents
Florida State vs. Louisville Odds and Betting Line
| Favorite | Spread | Favorite spread odds | Underdog spread odds | Total | Over total odds | Under total odds |
|---|---|---|---|---|---|---|
| Seminoles | -2 | -111 | -110 | 54.5 | -113 | -110 |
Florida State vs. Louisville Game Info
- Game Day: Friday, September 16, 2022
- Game Time: 7:30 PM ET
- TV Channel: ESPN
- Location: Louisville, Kentucky
- Stadium: Cardinal Stadium
Florida State vs. Louisville Prediction and Computer Picks
| Spread Pick | Total Pick | Predicted Score |
|---|---|---|
| Cardinals (+2) | Over (54.5) | Cardinals 30, Seminoles 28 |
Florida State vs. Louisville Betting Trends
Florida State Leaders
Florida State Season Stats
| Stat | Average (Total) | Rank |
|---|---|---|
| Pass yards | 201.6 (2419) | 95 |
| Rush yards | 177.8 (2134) | 52 |
| Points scored | 27.6 (331) | 81 |
| Pass yards against | 233.2 (2798) | 75 |
| Rush yards against | 144.6 (1735) | 55 |
| Points allowed | 26.5 (318) | 68 |
Louisville vs. Florida State Betting Trends
Louisville Leaders
Louisville Season Stats
| Stat | Average (Total) | Rank |
|---|---|---|
| Pass yards | 236.4 (3073) | 66 |
| Rush yards | 210.2 (2733) | 22 |
| Points scored | 31.6 (411) | 43 |
| Pass yards against | 245.6 (3193) | 96 |
| Rush yards against | 157.7 (2050) | 75 |
| Points allowed | 27.3 (355) | 78 |
Betting Tips for Florida State vs. Louisville
After taking a look at all of the key stats and trends for this matchup, our best bet against the spread is Cardinals (+2). Our computer prediction sees the scoring going over the total of 54.5 points, with the teams finishing with a final score of Cardinals 30, Seminoles 28 once the game has been played.
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