ACC opponents match up when the Florida State Seminoles (2-0) and the Louisville Cardinals (1-1) play on Friday, September 16, 2022 at Cardinal Stadium. Find more below on the Seminoles vs. Cardinals betting line, injury report, head-to-head stats, best bets and more.
The Seminoles are favored, but by less than a field goal (-2), versus the Cardinals. The over/under for this game is 54.5 points.
Florida State vs. Louisville Odds and Betting Line
Seminoles vs Cardinals Betting Information
| Favorite |
Spread |
Favorite spread odds |
Underdog spread odds |
Total |
Over total odds |
Under total odds |
| Seminoles |
-2 |
-111 |
-110 |
54.5 |
-113 |
-110 |
Florida State vs. Louisville Game Info
- Game Day: Friday, September 16, 2022
- Game Time: 7:30 PM ET
- TV Channel: ESPN
- Location: Louisville, Kentucky
- Stadium: Cardinal Stadium
Florida State vs. Louisville Prediction and Computer Picks
Prediction for Seminoles vs Cardinals
| Spread Pick |
Total Pick |
Predicted Score |
|
Cardinals (+2)
|
Over (54.5)
|
Cardinals 30, Seminoles 28
|
Florida State vs. Louisville Betting Trends
Florida State beat the spread six times in 12 games last season.
Florida State had one win ATS (1-2) as a 2-point favorite or greater last season.
In 12 Florida State games last season, four went over the total.
Florida State Leaders
Jermaine Johnson amassed 11.5 sacks, 12.0 TFL and 72 tackles last season.
Florida State Season Stats
| Stat |
Average (Total) |
Rank |
| Pass yards |
201.6 (2419) |
95 |
| Rush yards |
177.8 (2134) |
52 |
| Points scored |
27.6 (331) |
81 |
| Pass yards against |
233.2 (2798) |
75 |
| Rush yards against |
144.6 (1735) |
55 |
| Points allowed |
26.5 (318) |
68 |
Louisville vs. Florida State Betting Trends
Louisville’s record against the spread last season was 6-7-0.
As 2-point underdogs or more, Louisville had two wins ATS (2-3) last season.
There were six Louisville games (out of 13) that hit the over last year.
Louisville Leaders
Last year Yasir Abdullah accumulated 10.0 sacks, 17.0 TFL and 63 tackles.
Louisville Season Stats
| Stat |
Average (Total) |
Rank |
| Pass yards |
236.4 (3073) |
66 |
| Rush yards |
210.2 (2733) |
22 |
| Points scored |
31.6 (411) |
43 |
| Pass yards against |
245.6 (3193) |
96 |
| Rush yards against |
157.7 (2050) |
75 |
| Points allowed |
27.3 (355) |
78 |
Betting Tips for Florida State vs. Louisville
After taking a look at all of the key stats and trends for this matchup, our best bet against the spread is Cardinals (+2). Our computer prediction sees the scoring going over the total of 54.5 points, with the teams finishing with a final score of Cardinals 30, Seminoles 28 once the game has been played.
