Giants vs. Padres Prediction, Betting Tips & Picks 5/20/2022

An NL West matchup Friday features the third-place San Francisco Giants (22-15) hosting the second-place San Diego Padres (24-14). The Giants (-111) are listed as favorites for the game, which gets underway at 10:15 PM ET from Oracle Park. San Francisco’s Jakob Junis gets the start, and he’ll go against San Diego’s Sean Manaea.

Giants vs. Padres Spread and Betting Line

Computer Predictions for Giants vs. Padres

Our computer pick: San Diego Padres (-109) and Over (7.5)

Giants vs. Padres Game Info

• San Francisco Giants probable starting pitcher: Jakob Junis
• San Diego Padres probable starting pitcher: Sean Manaea
• Game Day: Friday, May 20, 2022
• Game Time: 10:15 PM ET
• Location: San Francisco, California
• Stadium: Oracle Park

San Francisco Giants vs San Diego Padres Pitching Matchup

Giants Starter Jakob Junis

• The Giants are sending Junis (1-1) to make his third start of the season.
• In his last time out on Saturday, the righty tossed 5 2/3 innings against the St. Louis Cardinals, giving up two earned runs while surrendering six hits.
• In four appearances this season, he has a 1.74 ERA and 7.8 strikeouts per nine innings, while opponents are hitting .213 against him.
• Junis will look to build upon a five-game streak of lasting five or more innings (he’s averaging 5.1 innings per outing).
• He will face a Padres offense that ranks 11th in the league with 165 runs while batting .227 as a squad. It has a collective .354 slugging percentage (23rd in MLB play) and has hit a total of 30 home runs (22nd in MLB).

Padres Starter Sean Manaea

• The Padres will send Manaea (2-3) to the mound for his eighth start this season.
• The left-hander gave up three earned runs in seven innings pitched on Saturday in his last outing, a matchup with the Atlanta Braves.
• The 30-year-old has an ERA of 3.77 and 10.5 strikeouts per nine innings with an opponent batting average of .214 in seven games this season.
• He’s going for his fourth quality start in a row.
• Manaea will look to pitch five or more innings for the fourth start in a row.
• The Giants are batting .248 this season, fifth in MLB. They have a team slugging percentage of .393 (10th in the league) with 40 home runs.
• The left-hander has faced the Giants one time this season, allowing them to go 4-for-21 with two doubles and two RBI in six innings.
• Among qualified Major League pitchers this season, the 30-year-old’s 3.77 ERA ranks 40th, 1.116 WHIP ranks 26th, and 10.5 K/9 ranks eighth.

Giants Betting Picks & Insights

• The Giants have won 20, or 66.7%, of the 30 games they’ve played as favorites this season.
• This season, San Francisco has won 20 of its 30 games, or 66.7%, when favored by at least -111 on the moneyline.
• The Giants have a 52.6% chance to win this game based on the implied probability of the moneyline.
• Games involving San Francisco have gone over the total set by sportsbooks in 20 of 38 chances this season.
• The Giants are 18-19-0 against the spread in their 37 chances this season.

Padres Betting Picks & Insights

• The Padres have won in six, or 50%, of the 12 contests they have been named as odds-on underdogs in this year.
• San Diego has a win-loss record of 6-6 when favored by -109 or worse by bookmakers this year.
• The Padres have an implied victory probability of 52.2% according to the moneyline set by sportsbooks for this matchup.
• San Diego and its opponents have gone over the total this season in 19 of their 39 opportunities.
• The Padres are 21-18-0 against the spread in their 39 games that had a posted line this season.

Giants Leaders & Batting Stats

• Thairo Estrada comes into Friday’s game hitting .271 with 20 RBI, both team-leading marks for the Giants. He has also connected on two round-trippers in 2022.
• Estrada is 173rd in homers and 45th in RBI among all hitters in the majors.
• Estrada carries a three-game hitting streak into this matchup. In his last five games he is batting .389 with two doubles, two walks and two RBI.
• Wilmer Flores has made the most of his opportunities as he leads his team with 20 runs batted in.
• Including all major league hitters, Flores is 117th in homers and 45th in RBI.
• Flores heads into this game looking for his third game in a row with a hit. In his last five games he is hitting .267 with two doubles, a walk and an RBI.
• Mike Yastrzemski has six doubles, three home runs and 12 walks while batting .290.
• Yastrzemski is on a three-game hitting streak entering this contest. During his last five outings he is batting .375 with three doubles, a home run, two walks and five RBI.
• Brandon Crawford is hitting .222 with five doubles, a triple, three home runs and 13 walks.
• Crawford is riding a two-game hitting streak into this one. During his last five outings he is batting .222 with a triple and an RBI.

Padres Leaders & Batting Stats

• Manny Machado paces the Padres with seven homers while posting a team-best batting average of .355.
• In all of the majors, Machado ranks 25th in homers and 21st in RBI.
• Machado carries a three-game hitting streak into this matchup. During his last five outings he is hitting .235 with a walk and an RBI.
• Eric Hosmer has capitalized on opportunities as he paces his team with 24 RBI.
• Hosmer is 74th in homers and 17th in RBI among all MLB batters this year.
• Jurickson Profar is batting .192 with eight doubles, a triple, five home runs and 22 walks.
• Ha-Seong Kim has six doubles, a triple, four home runs and 14 walks while batting .221.

Betting Tips for Giants vs. Padres

Our best bet is the Padres on the moneyline at -109 after looking at all of the key stats and trends for this matchup. Our computer predicts the total score will over the total of 7.5 runs.