Padres vs. Pirates Prediction, Betting Tips & Picks 5/27/2022

The San Diego Padres (28-16) host the Pittsburgh Pirates (18-25) on Friday to start a three-game series, with the first pitch at 9:40 PM ET from PETCO Park. The Padres are listed as -200 favorites, while the underdog Pirates have +170 odds on the moneyline. San Diego’s Sean Manaea gets the start, and he’ll go against Pittsburgh’s Jose Quintana.

Padres vs. Pirates Spread and Betting Line

Computer Predictions for Padres vs. Pirates

Our computer pick: Pittsburgh Pirates (+170) and Over (6.5)

Padres vs. Pirates Game Info

• San Diego Padres probable starting pitcher: Sean Manaea
• Pittsburgh Pirates probable starting pitcher: José Quintana
• Game Day: Friday, May 27, 2022
• Game Time: 9:40 PM ET
• Location: San Diego, California
• Stadium: PETCO Park

San Diego Padres vs Pittsburgh Pirates Pitching Matchup

Padres Starter Sean Manaea

• Manaea gets the start for the Padres, his ninth of the season. He is 2-3 with a 4.04 ERA and 55 strikeouts in 49 innings pitched.
• In his most recent appearance on Saturday, the left-hander went six innings against the San Francisco Giants, giving up four earned runs while surrendering five hits.
• The 30-year-old has put up an ERA of 4.04, with 10.1 strikeouts per nine innings, in eight games this season. Opponents have a .215 batting average against him.
• Manaea has six quality starts under his belt this season.
• Manaea will aim to go five or more innings for his fifth straight start. He’s averaging 6.0 frames per outing.
• He will take the mound against a Pirates offense that is batting .225 as a unit (24th in MLB). It is also slugging a collective .353 (26th in MLB) with 34 total home runs (25th in MLB).
• Manaea has pitched 6 2/3 innings, giving up three earned runs on five hits while striking out six against the Pirates this season.
• Among qualifying pitchers in MLB play this season, the 30-year-old’s 4.04 ERA ranks 42nd, 1.122 WHIP ranks 28th, and 10.1 K/9 ranks 11th.

Pirates Starter José Quintana

• Quintana (1-2) will take to the mound for the Pirates and make his ninth start of the season.
• The left-hander gave up two earned runs in 3 2/3 innings pitched on Saturday in his last outing, a matchup with the St. Louis Cardinals.
• The 33-year-old has an ERA of 2.43 and 7.5 strikeouts per nine innings with an opponent batting average of .216 in eight games this season.
• He has started eight games this season, earning a quality start (6 or more IP, 3 or fewer ER) in two of them.
• In eight starts this season, Quintana has lasted five or more innings five times, with an average of 5.0 innings per appearance.
• The Padres have scored 190 runs this season, which ranks 11th in MLB. They have 341 hits, 15th in baseball, with 32 home runs (26th in the league).

Padres Betting Picks & Insights

• The Padres have been favorites in 29 games this season and won 19 (65.5%) of those contests.
• San Diego has played as a favorite of -200 or more once this season and won that game.
• The sportsbooks’ moneyline implies a 66.7% chance of a victory for the Padres.
• San Diego and its opponents have gone over the total this season in 21 of their 45 opportunities.
• The Padres are 24-21-0 against the spread this season.

Pirates Betting Picks & Insights

• The Pirates have been underdogs in 32 games this season and have come away with the win 12 times (37.5%) in those contests.
• Pittsburgh has a mark of 2-3 in contests where sportsbooks favor them by +170 or worse on the moneyline.
• The Pirates have an implied victory probability of 37% according to the moneyline set for this matchup.
• Pittsburgh and its opponents have gone over the total this season in 17 of their 43 opportunities.
• In 43 games with a line this season, the Pirates have a mark of 20-23-0 against the spread.

Padres Leaders & Batting Stats

• Manny Machado’s eight homers and 27 RBI both lead the Padres, on top of his team-high .361 average.
• Among all batters in MLB, Machado is 28th in homers and 18th in RBI.
• Jurickson Profar is hitting .212 with nine doubles, a triple, five home runs and 25 walks.
• Profar ranks 68th in homers and 72nd in RBI on the year.
• Eric Hosmer is hitting .325 with eight doubles, four home runs and 16 walks.
• Hosmer is on a four-game hitting streak entering this contest. During his last five outings he is batting .250 with three walks.
• Ha-Seong Kim is hitting .220 with seven doubles, a triple, four home runs and 14 walks.
• Kim takes a two-game streak with at least one hit into this one. In his last five games he is hitting .211 with a double and an RBI.

Pirates Leaders & Batting Stats

• Ke’Bryan Hayes leads the Pirates with a .272 batting average.
• Hayes’ home run total puts him 327th in MLB, and he ranks 179th in RBI.
• Ben Gamel has driven in the most runs for the Pirates with 17 runs batted in.
• Among all major league hitters, Gamel ranks 148th in home runs and 111th in RBI.
• Bryan Reynolds has five home runs, tops in the clubhouse.
• Michael Chavis is batting .291 with five doubles, two triples, four home runs and five walks.

Betting Tips for Padres vs. Pirates

Our best bet is the Pirates on the moneyline at +170 after analyzing all of the key trends and stats for this matchup. Our computer projects the scoring will over the total of 6.5 runs.