Red Sox vs. Astros Prediction, Betting Tips & Picks 5/16/2022

The Boston Red Sox (13-21) hope to avoid an upset as -123 favorites when they take on Jose Altuve (with homers in two straight contests) and the Houston Astros (23-12). First pitch is at 7:10 PM ET Monday, live from Fenway Park. Garrett Whitlock will get the ball for Boston while Houston counter with Jake Odorizzi.

Red Sox vs. Astros Spread and Betting Line

Computer Predictions for Red Sox vs. Astros

Our computer pick: Houston Astros (+103) and Over (8.5)

Red Sox vs. Astros Game Info

• Boston Red Sox probable starting pitcher: Garrett Whitlock
• Houston Astros probable starting pitcher: Jake Odorizzi
• Game Day: Monday, May 16, 2022
• Game Time: 7:10 PM ET
• Location: Boston, Massachusetts
• Stadium: Fenway Park

Boston Red Sox vs Houston Astros Pitching Matchup

Red Sox Starter Garrett Whitlock

• Whitlock makes the start for the Red Sox, his fifth of the season. He is 1-1 with a 2.19 ERA and 34 strikeouts in 24 2/3 innings pitched.
• The right-hander’s last appearance came on Tuesday against the Atlanta Braves, when he went three innings, surrendering three earned runs while giving up four hits.
• The 25-year-old has amassed an ERA of 2.19, with 12.4 strikeouts per nine innings, in eight games this season. Opponents have a .169 batting average against him.
• He will face off against an Astros squad that is batting .229 as a unit (19th in MLB). It is also slugging a collective .407 (sixth in MLB) with 48 total home runs (third in MLB).

Astros Starter Jake Odorizzi

• The Astros will send Odorizzi (3-2) to the mound for his seventh start this season.
• The right-hander did not allow a run in five innings pitched on Sunday, May 8 in his last outing, a matchup with the Detroit Tigers.
• The 32-year-old has pitched in six games this season with an ERA of 3.37, a 1.545 strikeout to walk ratio and a WHIP of 1.238.
• In six starts this season, he’s earned two quality starts.
• Odorizzi has pitched five or more innings in three straight games and will look to extend that streak.
• The Red Sox have scored 126 runs this season, which ranks 23rd in MLB. They are batting .235 for the campaign with 20 home runs, 28th in the league.

Red Sox Betting Picks & Insights

• The Red Sox have been favorites in 14 games this season and won six (42.9%) of those contests.
• Boston has a record of 6-8, a 42.9% win rate, when favored by -123 or more by bookmakers this season.
• The bookmakers’ moneyline implies a 55.2% chance of a victory for the Red Sox.
• Boston’s games have gone over the total in 10 of their 34 chances.
• In 34 games with a spread this season, the Red Sox are 17-17-0 ATS.

Astros Betting Picks & Insights

• The Astros have been chosen as underdogs in eight games this year and have walked away with the win three times (37.5%) in those games.
• This year, Houston has won three of six games when listed as at least +103 or worse on the moneyline.
• The moneyline set for this matchup implies the Astros have a 49.3% chance of coming away with a victory in the contest.
• Houston and its opponents have gone over the total this season in 10 of their 35 opportunities.
• The Astros are 19-16-0 against the spread in their 35 games that had a posted line this season.

Red Sox Leaders & Batting Stats

• The Red Sox best power option comes in the form of Rafael Devers and his six-home-run 19-RBI season, both team highs.
• In all of Major League Baseball, Devers is 27th in homers and 41st in RBI.
• Devers carries a nine-game hitting streak into this matchup. During his last 10 games he is hitting .390 with six doubles, two home runs, four walks and nine RBI.
• Xander Bogaerts’ .344 batting average paces his team.
• Bogaerts is 152nd in homers in baseball, and 110th in RBI.
• Bogaerts carries a three-game streak with at least one hit into this contest. During his last five outings he is batting .350 with two walks and three RBI.
• J.D. Martinez is batting .314 with 11 doubles, four home runs and eight walks.
• Martinez is on a 16-game hitting streak entering this contest. During his last 10 games he is hitting .310 with three doubles, a home run, three walks and three RBI.
• Alex Verdugo is hitting .212 with five doubles, three home runs and eight walks.

Astros Leaders & Batting Stats

• Yordan Alvarez paces the Astros with 11 long balls.
• Alvarez ranks second in homers and 25th in RBI among all hitters in the majors.
• Alex Bregman has collected 22 runs batted in to lead his team.
• Bregman ranks 43rd overall in homers and 20th in RBI this year.
• Kyle Tucker has six doubles, five home runs and 20 walks while batting .254.
• Jeremy Pena leads the Astros with a team-leading batting average of .276.

Betting Tips for Red Sox vs. Astros

After taking a look at all of the key stats and trends for this matchup, our best bet is the Astros on the moneyline at +103. Our computer prediction sees the scoring going over the total of 8.5 runs.