Reds vs. Cubs Prediction, Betting Tips & Picks 5/25/2022

The Chicago Cubs (18-24) will lean on Frank Schwindel, following a two-homer game, to lead them in a matchup with the Cincinnati Reds (12-30) on Wednesday at 6:40 PM ET. The Cubs are +110 underdogs for the contest, according to sportsbooks. Luis Castillo will get the ball for Cincinnati while Chicago counter with Kyle Hendricks.

Reds vs. Cubs Spread and Betting Line

Computer Predictions for Reds vs. Cubs

Our computer pick: Chicago Cubs (+110) and Over (8.5)

Reds vs. Cubs Game Info

• Cincinnati Reds probable starting pitcher: Luis Castillo
• Chicago Cubs probable starting pitcher: Kyle Hendricks
• Game Day: Wednesday, May 25, 2022
• Game Time: 6:40 PM ET
• Location: Cincinnati, Ohio
• Stadium: Great American Ball Park

Cincinnati Reds vs Chicago Cubs Pitching Matchup

Reds Starter Luis Castillo

• Castillo (0-2) gets the starting nod for the Reds in his fourth start of the season. He’s put together a 4.60 ERA in 15 2/3 innings pitched, with 12 strikeouts.
• The righty last appeared on Friday against the Toronto Blue Jays, when he went six innings, allowing two earned runs while giving up seven hits.
• In three games this season, the 29-year-old has amassed an ERA of 4.60, with 6.9 strikeouts per nine innings. Opponents are batting .233 against him.
• Castillo is seeking his third straight appearance lasting five or more innings. He averages 5.1 frames per appearance on the hill.
• He will match up with a Cubs offense that ranks 17th in MLB with 328 total hits (on a .236 batting average). The team also slugs a collective .384 (17th in MLB) with 41 total home runs (14th in MLB).

Cubs Starter Kyle Hendricks

• Hendricks (2-4) will take the mound for the Cubs, his 10th start of the season.
• The right-hander last pitched on Friday, when he gave up seven earned runs and allowed eight hits in five innings against the Arizona Diamondbacks.
• The 32-year-old has pitched in nine games this season with an ERA of 4.89, a 2.059 strikeout to walk ratio and a WHIP of 1.329.
• In nine starts this season, he’s earned a quality start in two of them.
• Hendricks has pitched five or more innings in four straight games and will look to extend that streak.
• The Reds rank 28th in MLB with a .217 batting average this season. They have a team slugging percentage that ranks 26th in the league (.352) and 36 home runs.
• The 32-year-old’s 4.89 ERA ranks 55th, 1.329 WHIP ranks 48th, and 6.3 K/9 ranks 53rd among qualified pitchers in the majors this year.

Reds Betting Picks & Insights

• The Reds have won one of the six games they’ve played as favorites this season.
• Cincinnati has played as a favorite of -130 or more once this season and won that game.
• The Reds have a 56.5% chance to win this game based on the implied probability of the moneyline.
• Cincinnati’s games have gone over the total in 25 of their 43 chances.
• The Reds are 19-24-0 against the spread in their 43 chances this season.

Cubs Betting Picks & Insights

• The Cubs have won in 12, or 42.9%, of the 28 contests they have been named as odds-on underdogs in this year.
• This year, Chicago has won nine of 20 games when listed as at least +110 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Cubs have a 47.6% chance of pulling out a win.
• Chicago and their opponents have gone over in 21 of their 42 games with a total set by sportsbooks this season.
• The Cubs have posted a record of 22-20-0 against the spread this season.

Reds Leaders & Batting Stats

• Brandon Drury leads the Reds in home runs (seven) and runs batted in (22).
• Drury is 32nd in home runs and 42nd in RBI among all hitters in MLB.
• Drury brings a hitting streak of three games into this game. In his last five games he is hitting .158 with a double and three walks.
• Tyler Naquin has 22 RBI while batting .270. Both pace his team.
• Naquin is 63rd in home runs and 42nd in RBI among all hitters in MLB.
• Tommy Pham has five doubles, five home runs and 24 walks while batting .218.
• Kyle Farmer is batting .227 with 11 doubles, a home run and seven walks.
• Farmer has recorded at least one hit in five games in a row. During his last five outings he is hitting .444 with three doubles and three RBI.

Cubs Leaders & Batting Stats

• Ian Happ leads the team in batting average with a mark of .275.
• Among all batters in the majors, Happ’s home run total ranks 88th and his RBI tally ranks 42nd.
• Willson Contreras has seven doubles, a triple, five home runs and 16 walks while batting .258.
• Among all MLB batters, Contreras ranks 63rd in home runs and 143rd in RBI.
• Seiya Suzuki has 12 doubles, a triple, four home runs and 20 walks while hitting .239.
• Patrick Wisdom paces the Cubs in home runs (10) and runs batted in (23).

Betting Tips for Reds vs. Cubs

After looking at all of the key stats and trends for this matchup, our best bet is the Cubs on the moneyline at +110. Our computer picks see the scoring going over the total of 8.5 runs.