San Francisco Giants vs. Cleveland Guardians MLB Betting Tips and Best Bets

The Cleveland Guardians (4-2) and Myles Straw, coming off a four-hit game, are underdogs (+145) on the moneyline and will look to upset the San Francisco Giants (4-2) on Friday at 7:10 PM ET. Carlos Rodon will get the ball for San Francisco while Cleveland counter with Zach Plesac.

San Francisco Giants vs. Cleveland Guardians: Predictions, Betting Odds, Spread, Line

Computer Predictions for Giants vs. Guardians

Our computer pick: Cleveland Guardians (+145) and Over (8.5)

Giants vs. Guardians Game Info

• San Francisco Giants probable starting pitcher: Carlos Rodón
• Cleveland Guardians probable starting pitcher: Zach Plesac
• Game Day: Friday, April 15, 2022
• Game Time: 7:10 PM ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field

San Francisco Giants vs Cleveland Guardians Pitching Matchup

Giants Starter Carlos Rodón

• Rodon (0-0) starts for the Giants, his second this season.
• His most recent time out came on Saturday against the Miami Marlins, when the left-hander went 5 2/3 innings, surrendering one earned run while giving up three hits.
• Opposing hitters have a collective batting average of only .167 against him this season. He has a 1.80 ERA and 21.6 strikeouts per nine innings over his one appearances.
• He meets a Guardians offense that ranks first in the league with 45 runs while batting .308 as a unit. It has a collective .524 slugging percentage (second in MLB action) and has hit a total of nine home runs (second in MLB).

Guardians Starter Zach Plesac

• Plesac will get the start for the Guardians, his second of the season.
• The right-hander’s last appearance was on Saturday, when he threw 5 2/3 scoreless innings while allowing three hits against the Kansas City Royals.
• He has pitched to a .00 ERA this season with 4.8 strikeouts per nine innings compared to 0 walks per nine across one games.
• The Giants rank sixth in MLB with 27 runs scored this season. They have a .241 batting average this campaign with six home runs (11th in the league).

Giants Betting Picks & Insights

• Last season, the Giants won 70 out of the 98 games, or 71.4%, in which they were favored.
• San Francisco entered 47 games last season favored by -165 or more and was 35-12 in those contests.
• The implied probability of a win by the Giants, based on the moneyline, is 62.3%.
• San Francisco’s games went over the total in 74 of their 164 chances last season.
• The Giants were 74-46-0 against the spread in their 120 chances last season.

Guardians Betting Picks & Insights

• The Guardians won in 38, or 41.8%, of the 91 contests they were named as odds-on underdogs in last year.
• Last season, Cleveland was victorious 10 times in 29 chances when named as an underdog of +145 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 40.8% chance of coming away with a victory in the contest.
• Cleveland and its opponents went over the total last season in 82 of their 157 opportunities.
• The Guardians went 58-53-0 against the spread in their 111 games with a line set by sportsbooks last season.

Giants Leaders & Batting Stats

• Brandon Crawford put up a batting average of .298 with 90 runs batted in last season.
• Mike Yastrzemski had 28 doubles, three triples, 25 home runs and 51 walks while hitting .224.
• Wilmer Flores hit .262 a season ago with 16 doubles, a triple, 18 home runs and 41 walks.
• Brandon Belt hit 29 home runs on the season while slugging .597.

Guardians Leaders & Batting Stats

• Jose Ramirez put up 36 home runs and had 103 runs batted in last season.
• Straw hit .271 with 29 doubles, a triple, four home runs and 67 walks.
• Amed Rosario had a batting average of .282 with 155 total hits last season.
• Franmil Reyes had 18 doubles, two triples, 30 home runs and 43 walks while hitting .254.

Betting Tips for Giants vs. Guardians

We have the Guardians on the moneyline at +145 on the moneyline as our best bet in this contest after taking a look at all of the key trends and stats for this matchup. Our computer prediction sees the scoring going over the total of 8.5 runs.