San Francisco Giants vs. Cleveland Guardians Prediction, Betting Tips & Picks 4/16/2022

The Cleveland Guardians (4-3) will look to Jose Ramirez, with homers in two straight games, to pull off an upset win over the San Francisco Giants (5-2) Saturday at Progressive Field. The Giants are -116 moneyline favorites for the game, which starts at 6:10 PM ET. San Francisco’s Anthony DeSclafani and Cleveland’s Cal Quantrill have been named the starters for this contest.

San Francisco Giants vs. Cleveland Guardians: Predictions, Betting Odds, Spread, Line

Computer Predictions for Giants vs. Guardians

Our computer pick: Cleveland Guardians (-104) and Over (8)

Giants vs. Guardians Game Info

• San Francisco Giants probable starting pitcher: Anthony DeSclafani
• Cleveland Guardians probable starting pitcher: Cal Quantrill
• Game Day: Saturday, April 16, 2022
• Game Time: 6:10 PM ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field

San Francisco Giants vs Cleveland Guardians Pitching Matchup

Giants Starter Anthony DeSclafani

• DeSclafani (0-0) makes the start for the Giants, his second of the season.
• In his most recent time out on Sunday, the right-hander tossed 3 2/3 innings against the Miami Marlins, giving up two earned runs while surrendering eight hits.
• In one appearances this season, he has compiled a 4.91 ERA and averages 12.3 strikeouts per nine innings while opposing batters are hitting .471 against him.
• The opposing Guardians offense has the second-ranked slugging percentage (.486) and ranks fifth in MLB play with nine home runs. It has a collective .286 batting average, and is second in MLB with 73 total hits and first in MLB action scoring 46 runs.

Guardians Starter Cal Quantrill

• Quantrill heads to the mound for the Guardians to make his second start of the season, seeking his second win.
• The right-hander last pitched on Sunday, when he threw five innings against the Kansas City Royals, giving up two earned runs.
• He has an ERA of 3.60, a batting average against of .211 and 3.6 strikeouts per nine innings in one games this season.
• The Giants rank 14th in MLB with 31 runs scored this season. They have a .238 batting average this campaign with nine home runs (fifth in the league).

Giants Betting Picks & Insights

• The Giants have been favorites in seven games this season and won five (71.4%) of those contests.
• San Francisco has a record of 4-2 in games where sportsbooks favor them by at least -116 on the moneyline.
• The bookmakers’ moneyline implies a 53.7% chance of a victory for the Giants.
• San Francisco’s games have gone over the total in two of their seven chances.
• In seven games with a spread this season, the Giants are 2-5-0 ATS.

Guardians Betting Picks & Insights

• The Guardians were victorious in 38, or 41.8%, of the 91 contests they were chosen as underdogs in last season.
• Last season, Cleveland was victorious 34 times in 85 chances when named as an underdog of -104 or longer on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 51% chance of walking away with the win.
• Cleveland and its opponents hit the over in 82 of their 157 games with a total set by oddsmakers last season.
• The Guardians had an against the spread mark of 58-53-0 in 111 games with a line last season.

Giants Leaders & Batting Stats

• Brandon Belt’s .368 average and two homers both put him atop the Giants leaderboard this season.
• Among all hitters in the majors, Belt ranks 14th in homers and 91st in RBI.
• Belt brings a hitting streak of two games into this matchup. In his last five games he is hitting .368 with a double, two home runs, five walks and three RBI.
• Thairo Estrada has collected four runs batted in to pace his team.
• Of all major league hitters, Estrada is 51st in homers and 61st in RBI.
• Joey Bart leads the Giants with two home runs and four runs batted in.
• Wilmer Flores has two doubles, a home run and a walk while hitting .273.
• Flores is riding a two-game hitting streak into this one. In his last five games he is batting .333 with two doubles, a home run, a walk and three RBI.

Guardians Leaders & Batting Stats

• Ramirez had 36 home runs and 103 runs batted in last season.
• Myles Straw had 29 doubles, a triple, four home runs and 67 walks while hitting .271.
• Amed Rosario had a batting average of .282 with 155 total hits last season.
• Franmil Reyes hit .254 with 18 doubles, two triples, 30 home runs and 43 walks.

Betting Tips for Giants vs. Guardians

We have the Guardians on the moneyline at -104 on the moneyline as our best bet in this contest after taking a look at all of the key stats and trends for this matchup. Our computer picks see the scoring going over the total of 8 runs.