White Sox vs. Guardians Prediction, Computer Picks, Odds & Pitching Matchup 7/22/2022

The Chicago White Sox (46-46) will meet the Cleveland Guardians (46-44) on Friday at 8:10 PM ET. Amed Rosario will be looking for his 100th hit of the season for the underdog Guardians (+139) when the game gets underway at Guaranteed Rate Field. Chicago’s Lucas Giolito and Cleveland’s Cal Quantrill have been named the starters for this contest.

White Sox vs. Guardians Spread and Betting Line

Computer Predictions for White Sox vs. Guardians

Our best bet is the Guardians on the moneyline at +139 after digging through all of the key stats and trends for this matchup. Our computer predicts the scoring will over the total of 8 runs.

Our computer pick: Cleveland Guardians (+139) and Over (8)

White Sox vs. Guardians Game Info

• Chicago White Sox probable starting pitcher: Lucas Giolito
• Cleveland Guardians probable starting pitcher: Cal Quantrill
• Game Day: Friday, July 22, 2022
• Game Time: 8:10 PM ET
• Location: Chicago, Illinois
• Stadium: Guaranteed Rate Field

Chicago White Sox vs Cleveland Guardians Pitching Matchup

White Sox Starter Lucas Giolito

• Giolito makes the start for the White Sox, his 17th of the season. He is 6-5 with a 4.69 ERA and 102 strikeouts in 88 1/3 innings pitched.
• The righty last pitched on Wednesday, July 13 against the Cleveland Guardians, when he tossed 6 1/3 innings, allowing no earned runs while giving up five hits.
• In 16 games this season, the 28-year-old has amassed an ERA of 4.69, with 10.4 strikeouts per nine innings. Opponents are hitting .271 against him.
• Giolito heads into this matchup with seven quality starts under his belt this year.
• Giolito will look to go five or more innings for his ninth straight appearance. He’s averaging 5.2 frames per outing.
• He will face off against a Guardians offense that ranks 14th in MLB with 759 total hits (on a .249 batting average). The team also slugs a collective .384 (18th in MLB) with 71 total home runs (28th in MLB).
• Giolito has thrown 13 1/3 innings, giving up one earned run on 11 hits while striking out 10 against the Guardians this season.

Guardians Starter Cal Quantrill

• Quantrill (6-5) will take to the mound for the Guardians and make his 18th start of the season.
• The right-hander’s last appearance was on Saturday, when he threw six scoreless innings against the Detroit Tigers while allowing four hits.
• The 27-year-old has an ERA of 3.75, a 2.1 strikeout to walk ratio and a WHIP of 1.301 in 17 games this season.
• He has 10 quality starts in 17 chances this season.
• Quantrill will look to pitch five or more innings for the third start in a row.
• The White Sox have scored 406 runs this season, which ranks 15th in MLB. They have 824 hits, third in baseball, with 80 home runs (24th in the league).
• The White Sox have gone 18-for-52 with three doubles, two home runs and eight RBI in two games against the right-hander this season.
• The 27-year-old ranks 42nd in ERA (3.75), 50th in WHIP (1.301), and 60th in K/9 (5.6) among qualified pitchers in the majors this campaign.

White Sox Betting Picks & Insights

• The White Sox have entered the game as favorites 56 times this season and won 29, or 51.8%, of those games.
• Chicago has a record of 9-8 in games where sportsbooks favor them by at least -162 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the White Sox have a 61.8% chance to win.
• Chicago’s games have gone over the total in 43 of their 97 chances.
• In 97 games with a spread this season, the White Sox are 45-52-0 ATS.

Guardians Betting Picks & Insights

• The Guardians have been victorious in 21, or 42%, of the 50 contests they have been chosen as underdogs in this season.
• This year, Cleveland has won five of 18 games when listed as at least +139 or worse on the moneyline.
• The Guardians have an implied victory probability of 41.8% according to the moneyline set by sportsbooks for this matchup.
• Contests with Cleveland have gone over the total set by sportsbooks in 44 of 98 chances this season.
• The Guardians are 51-47-0 against the spread in their 98 games with a line set by sportsbooks this season.

White Sox Leaders & Batting Stats

• Jose Abreu is outstanding at both finding his way aboard and doing damage when he’s at the plate. Abreu leads the White Sox this season with a .387 OBP, .470 slugging percentage, and 105 hits.
• Including all MLB hitters, Abreu is 15th in batting average, 11th in on-base percentage, and 39th in slugging.
• Abreu carries an eight-game hitting streak into this matchup. In his last 10 outings he is batting .405 with two doubles, a home run, four walks and eight RBI.
• Luis Robert has put his power on display as he leads his team with 12 home runs and 54 runs batted in.
• Robert is 65th in homers and 22nd in RBI among all major league batters this year.
• Andrew Vaughn has 16 doubles, 10 home runs and 18 walks while batting .297.
• Vaughn will look to build on his four-game hitting in this game. In his last five games he is hitting .429 with two doubles, two home runs, a walk and 10 RBI.
• Tim Anderson has a club-best .310 batting average.
• Anderson is riding a six-game hitting streak into this one. During his last 10 outings he is hitting .295 with a double, a home run, two walks and four RBI.

Guardians Leaders & Batting Stats

• Jose Ramirez has a team-leading 19 home runs and has driven in 75 runs.
• Ramirez’s home run total places him 18th in MLB, and he ranks second in RBI.
• Ramirez carries a three-game hitting streak into this matchup. During his last five outings he is batting .300 with a double, two home runs, a walk and seven RBI.
• Rosario has 16 doubles, five triples, four home runs and 17 walks while batting .291.
• Rosario is 239th among all batters in the big leagues in homers, and 160th in RBI.
• Steven Kwan has 13 doubles, three triples, a home run and 32 walks while batting .279.
• Josh Naylor is hitting .274 with 13 doubles, 13 home runs and 18 walks.